Early exposure to hypertonic solution strongly intensifies the effects of K+ channel opener, rilmakalim, in guinea pig ventricular myocytes.
نویسندگان
چکیده
We report here that early exposure of guinea pig ventricular myocytes to hypertonic solution (approximately 400 mOsm compared to 280 mOsm in isotonic solution) increased the potency of rilmakalim to evoke ATP-sensitive K+ current 10 times (pD2 = 7.44 +/- 0.11 compared to pD2 = 6.49 +/- 0.18 in isotonic solution) without changing Emax, and observed effect was completely reversed by glibenclamide at 1 microM.
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ورودعنوان ژورنال:
- Polish journal of pharmacology
دوره 55 6 شماره
صفحات -
تاریخ انتشار 2003